For laboratory and educational use only. The compounds discussed are Research Use Only (RUO) materials, not approved for human or veterinary use. Nothing here is medical advice or an instruction for use in humans. See full disclaimer in the site footer.
The Regenesis Beauty Blend: GHK-Cu, Epithalon, NAD+ & Glutathione — What the Research Says
Research Disclaimer: Everything on PEPHUB is for educational and research purposes only. The compounds discussed here are supplied for laboratory research use only and are not intended for human consumption. Nothing in this article is medical advice.
"Beauty Blend" Sounds Like Marketing. The Formulation Says Otherwise.
The name Regenesis Beauty Blend is marketing language. Evaluating the formulation requires examining the ingredient research rather than the label.
The listed ingredients are GHK-Cu, Epithalon, NAD+ and Glutathione. Each has been investigated in aging-related biology, but ingredient research does not establish the effects of this combined formulation.
Research on GHK-Cu and NAD+ as individual compounds provides context for examining this combination. The ingredient literature spans chromosomes, mitochondria, the extracellular matrix and oxidative defense. These research areas overlap; distinct mechanisms do not prove synergy.
This review examines studies of each ingredient, possible mechanistic connections and the limits of the evidence.
Quick Answers
What's in the Regenesis Beauty Blend?
| Compound | Amount per vial | Primary research area | Level of aging targeted |
|---|---|---|---|
| GHK-Cu | 50 mg | Collagen, elastin, skin and tissue remodeling | Extracellular matrix |
| Glutathione | 200 mg | Antioxidant defense, melanin pathways | Oxidative stress |
| Epithalon | 5 mg | Telomerase activity, telomere length | Chromosome |
| NAD+ | 100 mg | Cellular energy, sirtuins, DNA repair | Mitochondria |
The Four Compounds, Broken Down
GHK-Cu (50 mg): The Rebuilder
GHK-Cu is a copper-bound tripeptide found naturally in human biological fluids. It shows up in plasma, saliva and urine, and its levels decline with age, in the research discussed by the cited review [2]. It was first isolated in 1973, and it's been one of the most-studied regenerative peptides ever since.
The skin research is where GHK-Cu earns its reputation. In cultured human dermal fibroblasts, GHK-Cu increased production of both collagen and elastin [1]. In a controlled cosmetic study of a topical formula, it reduced wrinkle volume by 55.8% versus a control serum and by 31.6% versus Matrixyl 3000 [1].
The bigger story is genetic. Using the Broad Institute's Connectivity Map, researchers found GHK shifts expression in roughly 31% of human genes by 50% or more, including genes associated with repair pathways [1]. That is the source of the "4,000 genes" claim discussed online.
Skeptic's note: most of the strongest GHK-Cu data is cell culture, animal wound models and topical cosmetic studies. It provides ingredient-level evidence, but it's not the same as data on a blend.
Epithalon (5 mg): The Wildcard
Epithalon (also spelled Epitalon) is a four-amino-acid peptide (Ala-Glu-Asp-Gly) developed from pineal gland research in St. Petersburg, Russia. Its evidence base warrants particularly careful interpretation.
The headline finding: in telomerase-negative human fetal fibroblasts, Epithalon induced telomerase activity, switched on the hTERT gene and lengthened telomeres [3]. Telomeres are protective chromosome caps that generally shorten during cell division. A 2004 follow-up from the same lab reported treated cells kept dividing for 44 passages versus 34 in controls [9].
Here's the part most vendor pages skip. Nearly all of that early work came from one research group. A 2025 independent study in Biogerontology did replicate telomere lengthening in normal human cell lines [4], providing independent cell-model evidence. But the same study saw a different telomere mechanism switch on in breast cancer cell lines, which is a reason for caution, not hype [4].
NAD+ (100 mg): The Power Supply
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme in every cell. It drives the redox reactions behind energy production, and it's the required fuel for sirtuins and PARPs, the enzyme families that handle DNA repair and gene regulation [5].
The aging connection is well documented: NAD+ levels decline with age in rodents and humans, and that decline is linked to metabolic, immune and neurological aging research [5]. Bonkowski and Sinclair's review lays out why sirtuins, the "longevity enzymes," can't do their job without enough NAD+ [6].
NAD+ participates in energy metabolism and serves as a substrate for sirtuins and PARPs. Those roles provide a possible mechanistic connection to tissue-remodeling and telomere research, not evidence that the ingredients act together in this vial.
Glutathione (200 mg): The Bodyguard
Glutathione is the body's most abundant internal antioxidant. Glutathione participates in cellular redox defense and the handling of reactive oxygen species. That established biochemical role does not show how the combined blend performs.
It's also the main reason this is called a beauty blend. In a 12-week randomized, double-blind, placebo-controlled trial, the investigators reported changes in melanin index, skin elasticity and wrinkle measures in the oral-glutathione study compared with placebo [7]. Those findings were modest and study-specific; they do not establish outcomes for a laboratory blend.
How the Four Research Areas May Connect
The ingredient literature covers four aging-related research areas. Whether the combined formulation produces complementary, competing or synergistic effects has not been established:
- Chromosome level: Epithalon is studied for telomerase activation and telomere length [3, 4]
- Mitochondrial level: NAD+ fuels energy production, sirtuins and DNA repair enzymes [5, 6]
- Extracellular matrix level: GHK-Cu has been studied for collagen, elastin and tissue remodeling [1, 2]
- Oxidative defense level: Glutathione participates in antioxidant and oxidative-stress pathways [7]
The Regenesis Loop: GHK-Cu tissue-remodeling research, NAD+ energy-metabolism research, glutathione redox biology and Epithalon telomere research suggest a possible mechanistic framework. This loop is a hypothesis, not a demonstrated effect of the combined blend.
The Honest Part: What the Research Doesn't Tell Us
The evidence has important limits.
No one has studied this blend. Every finding above comes from research on one compound at a time. Any proposed synergy remains a mechanistic hypothesis, not a finding from trial data.
Epithalon's human data is thin. The telomere findings are almost all cell culture and animal work, and most of it came from a single lab until the 2025 replication [3, 4].
GHK-Cu and Glutathione react with each other. This is the one nobody talks about. Glutathione is a reducing agent, and a 2021 study in Inorganic Chemistry showed glutathione reduces the copper in GHK-Cu from Cu(II) to Cu(I) through a short-lived intermediate complex [8]. In the body, the authors think this may actually be a natural step in delivering copper into cells [8]. In a combined vial, though, it raises a fair question about how stable the GHK-Cu complex stays over time.
This raises a need for third-party analytical documentation on the combined blend, not just on individual raw ingredients. A COA alone does not establish stability over time; stability data and assay conditions also matter.
Who Is the Regenesis Research Profile For?
Based on the compound mechanisms, this blend maps to four research areas:
- Skin and collagen research: GHK-Cu's collagen, elastin and remodeling data, plus glutathione's melanin-pathway studies [1, 7]
- Longevity and cellular aging research: telomere biology, sirtuins and NAD+ decline [3, 5, 6]
- DNA repair and cellular energy research: NAD+'s role as fuel for PARP and sirtuin enzymes [5]
- Oxidative stress research: glutathione's antioxidant role during active tissue repair [7]
The Aphrodite Blend breakdown examines energy and metabolism research. Regenesis brings together ingredients investigated in tissue structure, cellular renewal and longevity-related biology. Neither profile establishes effects of the combined formulations.
New to Researching Peptide Blends? Start Here.
PEPHUB has a free Reconstitution Guide for laboratory calculations and preparation concepts. It covers how to reconstitute a lyophilized (freeze-dried) blend, how to handle and store it, and how to use the blend calculator to set your volumes for lab work.
Reconstitution Solution selection, measurement accuracy and compound compatibility depend on the laboratory protocol; a calculator cannot establish formulation stability.
Before you start: researchpephub.com → Reconstitution Guide → Blend Calculator. Real research. No fluff.
Where to Find the Regenesis Blend
Use code PEPHUB at checkout.
The Regenesis Beauty Blend is a True Amino Labs formulation. Code PEPHUB works across every PEPHUB vendor partner, while vendor selection remains independent. PEPHUB is an education-first resource: we don’t rank vendors, and the choice is always yours.
Affiliate disclosure: PEPHUB may earn a commission from qualifying referrals.
Frequently Asked Questions
What's the difference between the Regenesis Blend and the Aphrodite Blend?
Aphrodite (MOTS-c, 5-Amino-1MQ, Lipo Pure, Glutathione, NAD+) is built around energy and metabolism. Regenesis (GHK-Cu, Epithalon, NAD+, Glutathione) is built around skin structure, cellular renewal and longevity.
Why does the Regenesis Blend include Epithalon?
Epithalon is the only compound in the blend studied for telomerase activation and telomere length, which adds a chromosome-level angle no other ingredient covers [3, 4].
Does glutathione interfere with GHK-Cu?
Glutathione can reduce the copper in GHK-Cu from Cu(II) to Cu(I) [8]. It's worth asking any vendor for a COA on the combined blend.
How much GHK-Cu is in the Regenesis Blend?
Each vial contains 50 mg GHK-Cu, 200 mg Glutathione, 5 mg Epithalon and 100 mg NAD+.
Where can I learn how to reconstitute the Regenesis Blend?
PEPHUB's free Reconstitution Guide and blend calculator at researchpephub.com walk through reconstitution, handling and storage for lab research.
Research Sources
All studies below were cell, animal or separate human studies of individual compounds. None tested the Regenesis Blend itself.
GHK-Cu
- Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018. https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/
- Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Res Int. 2015. https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/
Epithalon
- Khavinson VK, Bondarev IE, Butyugov AA. Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bull Exp Biol Med. 2003. https://www.doi.org/10.1023/A:1025493705728
- Al-dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025.
NAD+
- Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ Metabolism and Its Roles in Cellular Processes During Ageing. Nat Rev Mol Cell Biol. 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC7963035/
- Bonkowski MS, Sinclair DA. Slowing Ageing by Design: The Rise of NAD+ and Sirtuin-Activating Compounds. Nat Rev Mol Cell Biol. 2016. https://pmc.ncbi.nlm.nih.gov/articles/PMC5107309/
Glutathione
- Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and Its Antiaging and Antimelanogenic Effects. Clin Cosmet Investig Dermatol. 2017. https://www.dovepress.com/glutathione-and-its-antiaging-and-antimelanogenic-effects-peer-reviewed-fulltext-article-CCID
GHK-Cu + Glutathione chemistry
- Ufnalska I, et al. Intermediate Cu(II)-Thiolate Species in the Reduction of Cu(II)GHK by Glutathione. Inorg Chem. 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC8653159/
Epithalon follow-up
- Khavinson VK, Bondarev IE, Butyugov AA, Smirnova TD. Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004.
For research purposes only. The Regenesis Beauty Blend and its components are supplied for laboratory research use and are not intended for human consumption. PEPHUB does not provide medical advice, dosing guidance or usage instructions. PEPHUB may earn a commission from qualifying referrals using code PEPHUB.
⚠️ Disclaimer: This content is for laboratory and educational purposes only and reflects publicly available scientific literature and general discussion of the Research Use Only (RUO) market. It does not describe or endorse personal use, administration, or handling of any compound outside a controlled laboratory setting. These compounds are supplied strictly for laboratory research and are not approved for human or veterinary use. Nothing on this site is medical advice or an instruction for use in humans.